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中药材系
麻兵继,男,汉族,1975年12月生,安徽当涂人,中共党员。博士,教授,博士/硕士研究生导师。
研究领域:中药化学与生物学、中药材道地性形成机制研究。
所授课程:中药化学、中药与天然药物化学专论。
E-mail:mbj123@sina.com
教育与研究/工作经历
1994-1998,安徽中医药大学,药学院,中药学,学士;
1998-2000,安徽省马鞍山市精神康复医院,药剂师;
2000-2003,安徽中医药大学(中科院昆明植物研究所联合培养),中药学,硕士;
2003-2006,中国科学院昆明植物研究所(植物化学国家重点实验室),博士;
2006-2008,河南农业大学,农学院,中药材系,讲师;
2009-2014,河南农业大学,农学院,中药材系,副教授;
2011-2013,美国犹他州立大学,生物工程系,博士后;
2014-至今,河南农业大学,农学院,中药材系,教授;
2015-2016,美国犹他州生物创新中心,访问学者。
承担项目与课题
1. 国家自然科学基金面上项目:怀山药零余子多酚氧化酶基因鉴定及其解除休眠效应的机制研究,2025.1-2028.12,在研,主持;
2. 河南省省级科技研发计划联合基金项目(优势学科培育类):基于线粒体自噬研究熟地黄通过NLRP3/Caspase 1通路抗通风性关节炎的机制,2024.1-2025.12,在研,主持;
3. 河南省豫药全产业链研发协同创新中心开放课题:怀山药皮中多酚类物质的开发利用,2024.7-2026.6,在研,主持;
4. 河南省自然科学基金(重点项目):基于“锈斑”特异性的怀山药道地性形成机制研究,2023.1-2025.12,在研,主持;
5. 郑州市“1125”聚才计划(创新领军人才类),2019.1-2020.12,结题,主持;
6. 国家自然科学基金(河南联合基金):怀山药药材品质与内生真菌相关性研究,2017.1-2019.12,结题,主持;
7. 国际合作项目:Extraction, purification and analysis of ginsensides from Korean and hairy root ginseng for combine radiotherapy and chemotherapy cancer treatments,2015.5-2016.12,联合主持(合作对象为犹他州立大学Foster Agblevor教授),结题,主持;
8. 河南省基础与前沿技术研究计划项目:天然产物源高活性分子AV-1抗作物病原真菌机理研究,2014.1-2016.12,结题,主持;
9. 人社部留学归国人员科技活动择优资助项目,2014.1-2015.12,结题,主持;
10. 国家自然科学基金(青年项目):猴头菌子实体中刺激内源性神经生长因子合成活性成分研究,2010.1-2012.12,结题,主持;
11. 河南省科技攻关项目:人工蛹虫草核苷类物质发酵和超声提取工艺研究,2010.1-2011.12,结题,主持;
12. 植物化学与西部植物资源持续利用国家重点实验室开放课题:灵芝孢子抗烟碱活性物质研究,2010.1-2011.12,结题,主持。
论文、论著和专利
论文(*通讯作者):
1. Yahui Jia, Zhiqiang Zhang, Siming Zhang, Xia Ma, Yuan Ruan, Bingji Ma*, Li Wang*. Effects of polysaccharide from hot-compressed steamed Rehmannia glutinosa on the immune system and gut microbiota in an immunosuppressed mice model. International Immunopharmcology, 2024, 142, 113202. (SCI, IF: 4.8)
2. Tian Ruo-Dan, Sheng Meng-Ke, Zhao Ying-Fei, Chun-Nan Wen, Miao Liu*, Bing-Ji Ma*. α-pyrone derivatives from the endophytic Fusarium sp. L33 isolated from Dioscorea opposita, Phytochemistry Letters, 2024, 62, 14-17. (SCI, IF: 1.3)
3. Wang Li, Zhiqiang Zhang, Wanlin Zhao, Chaoyang Lin, Xianyu Zhou, Huili Pang, Guangyong Qin, Hui Li*, Bingji Ma*. Physicochemical, rheological, antioxidant and immunological properties of four novel non-inulin (poly)saccharides from Asparagus cochinchinensis. International Journal of Biological Macromolecules, 2024, 258, 129034. (SCI, IF: 8.2)
4. Yi Liu, Chao-fei Niu, Yi Wang, Yuan Ruan, Li Wang, Hui Li*, Bing-Ji Ma*. Preparation, structural characteristics and antioxidant activity of polysaccharide and its metal chelates from the peel of Disocorea oppositifolia L. Natural Product Research, 2023, e2255917 (SCI, IF: 1.9)
5. Zuowei Zhao, Yanyan Qian, Yuan Ruan, Menghuan Ge, Li Wang*, Bingji Ma*. Physicochemical properties and biological activities of polysaccharides from the peel of Dioscorea opposita Thunb. extracted by four different methods. Food Science and Human Wellness, 2023, 12, 130-139. (SCI, IF: 5.6)
6. Xinxin Li, Zhiqiang Zhang, Li Wang*, Haoqiang Zhao, Yahui Jia, Xia Ma*, Jinzhan Li, Yi Wang and Bingji Ma*. Three-phase extraction of polysaccharide from Stropharia rugosoannulata: Process optimization, structural characterization and bioactivities. Frontiers in Immunology, 2022, e994706. (SCI, IF: 5.7)
7. Yanyan Qian, Li Wang*, Zhiqiang Zhang*, Xin-xin Li, Chaofei Niu, Xiao Li, Erjuan Ning, Bingji Ma*. Physical-chemical properties of heteropolysaccharides from different processed forms of Rehmanniae radix. Process Biochemistry, 2022, 121, 481-492. (SCI, IF: 3.7)
8. Li Wang*,Zuowei Zhao, Haoqiang Zhao, Miao Liu, Chaoyang Lin, Lianzhen Li, Bingji Ma*. Pectin polysaccharide from Flos Magnoliae (Xin Yi, Magnolia biondii Pamp. flower buds) : Hot-compressed water extraction, purification and partial structural characterization. Food Hydrocolloids, 2022, 122: 107061. (SCI, IF: 11.0)
9. Yuan Ruan, Chaofei Niu, Pengzhan Zhang, Yanyan Qian, Xinxin Li, Li Wang* and Bingji Ma*. Acid-catalyzed water extraction of two polysaccharides from Artemisia argyi and their physicochemical properties and antioxidant activities. Gels, 2022, 8, 5. (SCI, IF: 5.0)
10. Li Wang, Yi-gui Mao, Xiang Zeng, Na Liu, Chao-fei Niu, Xin-xin Li, Bing-ji Ma*, Lan-ping Guo* and Xiao-long Yang*. Structure and bioactivities of a novel polysaccharide extracted from Dendrobium huoshanense by subcritical water. Frontiers in Nutrition, 2022, 9, 977871. (SCI, IF: 4.0)
11. Li Wang, Peng-zhan Zhang, Jin-wen Shen, Yan-yan Qian, Miao Liu, Yuan Ruan, Xu-guang Wang, Shao-ning Zhang, Bing-ji Ma*. Physicochemical properties and bioactivities of original and Se-enriched polysaccharides with different molecular weights extracted from Pleurotus ostreatus. International Journal of Biological Macromolecules, 2019, 141, 150-160. (SCI, IF: 8.2)
12. Bing-ji Ma*, Foster A. Agblevor. Separation and hydroprocessing of HZSM-5 catalytic olive mill waste sludge bio-oil. Energy & Fuels, 2016, 30(12), 10524-10533. (SCI, IF: 5.20)
13. Bing-ji Ma*, Foster A. Agblevor. Polarity-based separation and chemical characterization of fast pyrolysis bio-oil from poultry litter. Biomass & Bioenergy, 2014, 64(5), 337-347. (SCI, IF: 5.74)
14. Yuan Ruan, Bing-ji Ma*, Lianzhen Li, Xiaolong Wang. Specific 12α-hydroxylation of grandiflorenic acid by permeabilized fungus Fusarium graminerum. Natural Product Research, 2014, 28(9), 677-679. (SCI, IF: 1.9)
15. Jin-Wen Shen, Yuan Ruan, Wei Ren, Bing-Ji Ma*, Xiao-Long Wang, Chun-Feng Zheng. Lycorine: a potential broad-spectrum agent against crop pathogenic fungi. Journal of Microbiology and Biotechnology, 2014, 24(3): 354-358. (SCI, IF: 2.5)
16. Bing-ji Ma, Jia Zeng, Lei Shao, Jixun Zhan. Efficient bioconversion of quercetin into a novel glycoside by Streptomyces rimosus subsp. rimosus ATCC 10970. Journal of Bioscience and Bioengineering, 2013, 115(1), 24-26. (SCI, IF: 2.3)
17. Bing-Ji Ma, Chun-Nan Wen, Yuan Gao, Fu-Cai Ren, Fei Wang, Ji-Kai Liu. ent-Kaurane diterpenoids from the plant Wedelia trilobata. Natural Products and Bioprospecting, 2013, 3(3), 107-111. (SCI, IF: 4.8)
18. Bing-Ji Ma*, Yan Zhou, Yuan Ruan, JinChuan Ma, Wei Ren, ChunNan Wen. Lanostane-type triterpenes from the sporoderm-broken spores of Ganoderma lucidum. Journal of Antibiotics, 2012, 65(3), 165-167. (SCI, IF: 2.1)
19. BingJi Ma*, JinChuan Ma, Yuan Ruan. Hericenone L, a new aromatic compound from the fruiting bodies of Hericium erinaceum. Chinese Journal of Natural Medicines, 2012, 10(5): 363-365. (SCI, IF: 4.6)
20. Bing-Ji Ma*, Hai-You Yu, Jin-Wen Shen, Yuan Ruan, Xu Zhao, Han Zhou, Ting-Ting Wu. Cytotoxic aromatic compounds from Hericium erinaceum. Journal of Antibiotics, 2010, 63(12), 713-715. (SCI, IF: 2.1)
21. Bing-Ji Ma*, Jin-Wen Shen, Hai-You Yu, Yuan Ruan, Ting-Ting Wu, and Xu Zhao. Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus. Mycology, 2010, 1 (2), 92-98. (SCI, IF: 4.6)
22. Bing-Ji Ma*, Ting-Ting Wu, Yuan Ruan, Jin-Wen Shen, Han Zhou, Hai-You Yu, and Xu Zhao. Antibacterial and antifungal activity of scabronines G and H in vitro. Mycology, 2010, 1 (3), 200-203. (SCI, IF: 4.6)
23. Jin-Wen Shen, Yuan Ruan, Bing-Ji Ma*. Diterpenoids of macromycetes. Journal of Basic Microbiology, 2009, 49 (3), 242-255. (SCI, IF: 3.5)
24. Jin-Wen Shen, Bing-Ji Ma*. Activity of armillarisim B in vitro against plant pathogenic fungi. Z. Naturforsch, 2009, 64c. 790-792. (SCI, IF: 1.8)
25. Bing-Ji Ma* and Yuan Ruan. Egg white, a favourable solvent to extract the active ingredient of Mylabris phalerata. Z. Naturforsch, 2008, 63c, 619-620. (SCI, IF: 1.8)
26. Bing-Ji Ma*, Yan Zhou, Lian-Zhen Li, He-Min Li, Zhi-Ming Gao, and Yuan Ruan. A new cyathane-xyloside from the mycelia of Hericium erinaceum. Z. Naturforsch, 2008, 63b, 1241-1242. (SCI, IF: 0.96)
27. Bing-Ji Ma* and Yuan Ruan. Scabronine J, a new cyathane-type diterpenoid from the basidiomycete Sarcodon scabrosus. Journal of Antibiotics, 2008, 61 (2), 86-88. (SCI, IF: 2.1)
28. Bing-Ji Ma* and Yuan Ruan. Trametes versatillis, a fungus highly produces eburicoic acid. Z. Naturforsch, 2007, 62c, 909-910. (SCI, IF: 1.8)
论著/教材:
1. 《药食兼用真菌重要次生代谢产物及其生物活性研究》,独著,2011年11月,中国农业科学技术出版社;
2.《固体发酵工程原理及应用》,编委,2008年8月,中国轻工业出版社;
3. 全国高等中医药类21世纪创新教材《中药资源综合利用与产品开发》, 编委,2013年11月,中国中医药出版社;
4.《食用菌生产技术大全》,编委,2014年1月,河南科技出版社;
5. 普通高等教育“十三五”规划教材《天然产物结构解析》,编委,2017年11月,科学出版社;
6. 普通高等教育“十三五”规划教材《中药资源化学》,编委,2022年12月,中国中医药出版社;
7. 《民族植物资源化学与生物活性研究》,副主编,2022年5月,化工出版社。
国家发明专利:
1. “利用长毛囊孔菌发酵液进行分离制备齿孔酸化合物的方法”,授权专利号:ZL2006101283906.2(排名第1);
2. “一种从红乳菇子实体中提取分离红乳菇素的方法”,授权专利号:ZL200710189855.3(排名第1);
3. “一种制备化合物猴头菌素P的方法”,授权专利号:ZL200810231014(排名第1);
4.“岩白菜素异戊烯基衍生物及其制备方法和应用”,授权专利号:ZL200910064726.0(排名第2);
5.“一种栽培白灵菇的培养料配方”,授权专利号:ZL201010176702.7(排名第2);
6.“岩白菜素五乙酰化物及其应用”,授权专利号:ZL200510021308.5(排名第3);
7.“一种山药皮多糖及其制备方法与应用”,授权专利号:ZL202110171190.3(排名第2);
8.“高分子量地黄多糖的制备方法及高压蒸制鲜地黄获得熟地黄的方法”,授权专利号:ZL202110179163.0(排名第4)。
奖励与荣誉
1. 河南省教育厅学术技术带头人(2015年);
2. 河南省高校青年骨干教师(2009年);
3. 河南省科技特派员(2014、2015、2016、2017、2024年);
4. 河南农业大学优秀教师(2009年);
5. 河南省第九届挑战杯大学生课外学术科技作品竞赛优秀指导教师(作品获第河南省大学生挑战杯一等奖,2011年);
6. 河南省科技进步三等奖(2010年);
7. 南阳市科技进步一等奖三项(2011年、2013年和2014年);
8. 郑州市“1125”聚才计划(创新领军人才类)(2018年);
9. 河南省农产品加工技术专家(2019年);
10. 河南省研究生优秀论文指导老师(2019年);
11. 河南省药品审评查验中心专家(2024年);
12. 河南省禹州市、嵩县中药材产业发展顾问专家(2023、2024年);
13. 郑州市中药材种质资源创新与代谢工程重点实验室主任(2022年);
14. 河南省药学会中药资源专委会副主任委员(2019年)。